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Parents sometimes ask about using melatonin, usually in the form of chewable gummies, to aid sleep in their children. In the U.S., melatonin gummies are sold over the counter (OTC) as a supplement (without FDA approval). Investigators assessed the melatonin content of 25 unique brands of OTC melatonin gummies, some of which also listed cannabidiol (CBD) as an ingredient. Melatonin and CBD content was measured by liquid chromatography.
The purported melatonin content in the gummies ranged from 1 mg to 10 mg, whereas the actual content ranged from 1.3 mg to 31.1 mg. The ratio of actual-to-labeled content ranged from 74% to 347%. Only three products had melatonin concentrations that were within 10% of the labeled amount. One product contained n…