A Head-to-Head Comparison of Two Novel Markers for Predicting CHD

Findings are consistent with current guidelines prioritizing the coronary artery calcium score over the polygenic risk score in predicting patient risk.

The coronary artery calcium score and the polygenic risk score (PRS) are increasingly being used as adjuncts to risk assessments for coronary heart disease (CHD). Investigators sought to compare these markers for their ability to influence risk prediction.

They evaluated data from two population-based cohort studies comprising participants aged 45 to 79 years, including 1991 individuals from the Multi-Ethnic Study of Atherosclerosis and 1217 from the Rotterdam Study. In both cohorts, the coronary artery calcium score and PRS had a similar magnitude of association with CHD risk. The C-statistic, indicating risk discrimination performance, was 0.76 for the coronary artery calcium score and 0.69 for the PRS. When added to a traditional risk fac…

Reviewing Author

Harlan M. Krumholz, MD, SM

Disclosures

Consultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime

EquityHugo Health; Refactor Health; Element Science

Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association

Harlan M. Krumholz, MD, SM

Disclosures

Consultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime

EquityHugo Health; Refactor Health; Element Science

A Head-to-Head Comparison of Two Novel Markers for Predicting CHD

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Reviewing Author