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In 2020, the SCCM published recommendations (Crit Care Med 2020; 48:e173) focused on cardiovascular, hematologic, endocrine, renal, and pulmonary care of critically ill patients with acute liver failure (ALF) or acute-on-chronic liver failure (ACLF). Now, the society has published a second installment, which is focused on gastrointestinal bleeding and spontaneous bacterial peritonitis (SBP) in these patients.
Critically ill patients with ACLF and any form of upper gastrointestinal bleeding should be treated with prophylactic antibiotics, usually third-generation cephalosporins.
Critically ill patients with ACLF and portal hypertensive bleeding should be trea…