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With the development of highly effective direct-acting antivirals that are simple to administer and well-tolerated, the ability to eradicate chronic hepatitis C virus (HCV) globally is within reach. This updated version of a 2020 guideline (Hepatology 2020; 71:686) provides clinicians with a simple evidence-based approach.
To achieve global eradication, HCV screening should be performed in all adults (age, ≥18) and all pregnant people during each pregnancy. Subsequent linkage to treatment is emphasized.
In most settings, the preferred treatment regimen is glecaprevir/pibrentasvir for 8 wee…