Does Physical Activity Reduce the Risk for Parkinson Disease in Women?

The incidence of PD was lower among those with higher levels of physical activity.

Is physical activity (PA) associated with a lower incidence of Parkinson disease (PD) in women? To find out, investigators analyzed long-term data from the ongoing E3N cohort study of nearly 100,000 women affiliated with a French national health plan (Eur J Epidemiol 2022;37:513).

The researchers used lagged analyses to compare PA trajectories between 1196 PD cases and 23,879 matched controls and applied a time-varying latent PA (LPA) variable with latent-process mixed models. PD diagnosis was based on medical records or a validated drug claim algorithm, and a nested case-control study was applied to LPA trajectories using multivariable linear mixed models and a retrospective timescale. A Cox proportional hazards model using age as the times…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)