Promising Results with a Clostridioides difficile Vaccine

In a phase 2 study, neutralizing antibody to C. difficile toxins persisted 48 weeks after three doses and increased after a fourth dose.

Vaccination is one approach for preventing Clostridioides difficile infection (CDI). A previous study of a three-dose C. difficile vaccine using inactivated toxins A and B demonstrated immunogenicity for both monthly (0, 1, and 6 months) and daily (1, 8, and 30 days) regimens among healthy participants aged 65–85 without a prior history of CDI. Now, researchers report the results of a study extension in 300 participants randomized to receive a booster vaccination 12 months after primary immunization.

For the three-dose, 200-µg primary monthly regimen without boosting, neutralizing antibody to both toxin A and toxin B were detectable 48 months after the third immunization, with 24% of subjects remaining above a prespecified antibody level aga…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Promising Results with a Clostridioides difficile Vaccine

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Reviewing Author