Do Race, Sex, and Medical Conditions Affect Plasma Alzheimer Disease Biomarker Levels?

Levels of plasma Alzheimer disease biomarkers in a biracial community-based cohort differed by sex and medical conditions, but not race.

Social determinants of health and medical conditions may affect the interpretation of plasma biomarkers for Alzheimer disease (AD). In this community-based cross-sectional study, researchers analyzed the association of plasma AD biomarkers with cognition and medical conditions among Black people and non-Hispanic white (NHW) people. Plasma biomarkers included phosphorylated amyloid-beta 42/40, phosphorylated tau 181 (p-tau181), glial fibrillary acid protein (GFAP), and neurofilament light chain (NfL). Mini-Mental State Examination scores (MMSE) were used to assess cognition. Cognitive status (cognitively unimpaired, mild cognitive impairment, or dementia) was determined by a multidisciplinary consensus panel. Additional variables included ap…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Do Race, Sex, and Medical Conditions Affect Plasma Alzheimer Disease Biomarker Levels?

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Reviewing Author