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The prevalence of axonal polyneuropathy increases with age. However, accurate diagnosis can be challenging, as signs attributed to polyneuropathy have also been observed with increasing frequency in older adults without neuropathy. To quantify age-related changes, researchers examined a cohort of 4179 adults 40 years of age or older (mean, 65 years) enrolled in the population-based Rotterdam study. Exclusion criteria were a diagnosis of polyneuropathy by a neurologist or at least two of the following: ≥3 of 12 polyneuropathy symptoms, ≥2 findings on lower limb examination, or sural sensory nerve action potential (SNAP) amplitude <4.0 µV.
Among the 3780 (90.5%) participants without neuropathy, differences with age were most pronounced for vib…