Loading...
The American Academy of Pediatrics treatment guideline for acute pediatric sinusitis recommends: (1) using either amoxicillin or amoxicillin-clavulanate, and (2) using standard dose for uncomplicated sinusitis or high dose for more severe cases or in areas with high-prevalence resistance (Pediatrics 2013; 132:e262). Clinicians must choose between amoxicillin or amoxicillin-clavulanate empirically due to limited real-world information about their comparative effectiveness and safety.
Using national insurance claims data for 320,000 children who received either amoxicillin and amoxicillin-clavulanate for acute sinusitis, researchers compared rates of treatment failure and adverse outcomes. In the 14 days after antibiotics were prescribed, trea…