Donor-Derived Mycoplasma and Ureaplasma Species May Cause Severe Disease in Lung Transplant Recipients

Mollicutes species normally associated with urogenital infection can be transmitted from lung donor to recipient with poor outcomes despite treatment.

Certain species of mollicutes typically infect the urogenital tract, although extragenital infections can occur. As these organisms metabolize urea and arginine, lung donor-to-recipient transmission is associated with hyperammonemia syndrome (HS) characterized by often-fatal encephalopathy. Tam et al. have analyzed risk factors, clinical characteristics, and outcomes associated with donor-derived mollicutes infection after lung transplantation at one academic hospital from 2010 through 2019.

Among 1156 lung transplants, 27 recipients developed mollicutes infection (primarily with Mycoplasma hominis and Ureaplasma urealyticum). Donor characteristics independently associated with recipient infection included age <40, white race, and purulent s…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Donor-Derived Mycoplasma and Ureaplasma Species May Cause Severe Disease in Lung Transplant Recipients

Topics

Reviewing Author