Adding aerobic exercise to cognitive training for 12 weeks failed to improve information processing speed in patients with progressive MS.
Aerobic exercise has been hypothesized to improve cognitive performance and enhance rehabilitation strategies in patients with multiple sclerosis (MS), among other neurological diseases.
Now, investigators have conducted an international, randomized, multiple-arm, double-blind, sham-controlled study (CogEx) to further assess the possible synergistic effects of adding aerobic exercise to cognitive rehabilitation in 311 patients with progressive MS and cognitive impairment who were not engaged in physical training. Participants were assigned to one of following interventions, which were conducted twice per week for 12 weeks:
Cognitive rehabilitation plus exercise
Cognitive rehabilitation plus sham exercise
Exercise plus sham cognitive rehabilitat…
Reviewing Author
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)