Loading...
Rapidly progressive dementia (RPD) is a cognitive disorder characterized by decline in cognition from initial symptom onset to dementia within 2 years. A variety of conditions can manifest as RPD, including treatment-responsive conditions such as autoimmune encephalitis (AE), inflammatory vasculitis, primary central nervous system (CNS) lymphoma, and Wernicke encephalopathy, as well as treatment-nonresponsive conditions such as prion disease, Alzheimer disease, and glioblastoma multiforme. In a prospective observational study, researchers enrolled 226 adult patients with suspected RPD referred to two tertiary centers for evaluation over a 6.5-year period, of whom 71 had obvious discrete causes (e.g., ischemic or hemorrhagic stroke, or fulmi…