Subtyping Sepsis: Limited Common Ground?

Categorization of 522 sepsis cases by four subphenotyping strategies based on clinical, biomarker, and transcriptomic data yielded no correlation.

Bone et al.'s 1992 proposal to better characterize the definition of sepsis (NEJM JW Gen Med Jan 1993 and JAMA Dec 1992) has abundantly fueled subsequent research. Diagnostic criteria of sepsis have been modified several times (most recently in 2016 by Singer et al.) in an effort to describe this multifaceted syndrome more precisely, and investigators are attempting to delineate subphenotypes of sepsis according to clinical, biomarker, and transcriptomic data. How do such strategies correlate?

van Amstel et al. conducted a secondary analysis of 522 patients fulfilling current criteria for sepsis and severe sepsis who were originally enrolled in the Molecular Diagnosis and Risk Stratification of Sepsis (MARS) study (median age, 61; 57% male; …

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Subtyping Sepsis: Limited Common Ground?

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Reviewing Author