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Evidence is mixed on whether multidomain interventions — simultaneously targeting lifestyle, behavioral, and medical risk factors — can improve cognition or delay cognitive decline. For this pilot study, researchers identified 172 older adults (age range, 70–89) without dementia but with ≥2 dementia risk factors (i.e., physical inactivity, uncontrolled hypertension, poor sleep, taking medication that can affect cognition, depressive symptoms, uncontrolled diabetes, social isolation, or current smoking). They were randomized to an interventions group that set personalized risk-reduction goals, with health coaching and nurse visits offered every 4 to 6 weeks, or to a control group that received mailed educational materials.
After 2 years, both…