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Since its introduction, percutaneous coronary intervention (PCI) has been guided by coronary angiography. It is well recognized, however, that angiography alone cannot determine the functional significance of many coronary lesions and also fails to define pre- and post-PCI anatomic features (such as calcification, precise stent dimensions, and the presence of untreated dissections) that are important for PCI outcomes. Although both intravascular imaging via ultrasound or optical coherence tomography and functional guidance using wire-based physiology have been shown to improve clinical outcomes, the dominant approach in contemporary practice remains PCI based solely on angiographic guidance.
To compare these three different approaches to PCI…