Risks for Candidiasis and Invasive Mold Infection After Lung Transplantation

In a retrospective single-center analysis, invasive fungal infections occurred in 26.4% of patients receiving universal antifungal prophylaxis.

Recipients of lung transplants are at significant risk for invasive fungal infection (IFI) with yeast or mold throughout the first posttransplant year. Despite consensus that antifungal prophylaxis should be given during this time, the optimal strategy has not been defined.

At Duke University Medical Center, weekly inhaled amphotericin B lipid complex for 90 days after lung transplantation has been prescribed since 2000, and 400-mg daily fluconazole was added in 2015 to target invasive candidiasis (IC). To examine risks for early (≤90 days) and late (>90 days–1 year) IC and invasive mold infections (IMI), investigators retrospectively analyzed outcomes in 603 participants between 2012 and 2017. In all, 159 patients developed IFIs, of which 7…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Risks for Candidiasis and Invasive Mold Infection After Lung Transplantation

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Reviewing Author