Patterns of Cerebral Infarct Growth With and Without a Neuroprotectant Medication

Clinical trials of putative acute stroke treatments rely on clinical outcome measures, such as the modified Rankin scale at 90 days. Using radiology parameters such as extent of infarct growth from baseline to a defined post-treatment time period could be useful to establish suggestion of a treatment effect. For this report, researchers performed an MRI-based substudy from the larger ESCAPE NA1 trial, which enrolled patients who could be treated within 12 hours of stroke onset and treated with endovascular thrombectomy. In the main trial, patients received either nerinetide or placebo, with the hypothesis that nerinetide, which reduces excitotoxicity involved with the NMDA receptor, would improve clinical outcomes. In this substudy, an MRI …