Hypochlorous Acid–Producing Bandages: A Novel Treatment for Infected Wounds

Chronic wound infections represent a reservoir of multidrug-resistant pathogens. Pseudomonas aeruginosa is particularly problematic due to its acquired resistance superimposed on intrinsic resistance. Thus, strategies that reduce exposure of P. aeruginosa to antibiotics may help stem the tide of antibiotic resistance.

Fleming and colleagues evaluated a novel electrochemical bandage (e-bandage) that delivers low concentrations of the biocide hypochlorous acid (HOCl) to chronic wounds, producing antibacterial effects against P. aeruginosa without impairing wound healing. In a murine model, wounds were infected with P. aeruginosa that was permitted to form biofilms. Bandages consisted of Tegaderm only (control), a nonpolarized e-bandage (no HOC…