DaxibotulinumtoxinA Has Long Response Duration in Cervical Dystonia

In a randomized, controlled trial, the drug's efficacy lasted 20 to 24 weeks, depending on the dose.

BotulinumtoxinA is an established treatment for cervical dystonia, but its effects sometimes wear off before 12 weeks. A randomized, double-blind, placebo-controlled, manufacturer-funded study was conducted to determine the efficacy, duration of response, and safety of daxibotulinumtoxinA (DAXI), tested at two dose levels, for cervical dystonia. Included were adults with moderate-to-severe cervical dystonia treated at one of 60 study sites in nine countries. The randomization was 3:3:1 to a single dose of 125U or 250U of intramuscular DAXI or placebo. The primary outcome was a change from baseline in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score averaged across weeks 4 and 6.

Among 301 persons randomized, the active-treat…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)