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Antibiotics often are considered to be among the gentler and more comfort-oriented interventions in end-of-life care, certainly far less aggressive than intubation or last-ditch surgery. In a recent study, researchers estimated that close to 50% of terminally ill patients will receive one or more antibiotic courses in their last months (Clin Microbiol Infect 2023; 29:107.e1) Still, antibiotics do entail their own costs in the form of toxicities and need for intravenous access, and liberal antibiotic use reliably worsens institutional and community drug-resistance profiles. These considerations have prompted recent reexaminations of how best to approach antibiotic use in terminal illness (NEJM JW Gen Med Jan 15 2023 and J Antimicrob Chemothe…