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In patients with multivessel coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI), several recent trials have shown that outcomes are better when both the culprit lesion and angiographically severe nonculprit lesions are revascularized. Those studies selected patients for nonculprit-lesion PCI using angiographic assessment alone, which is known to be relatively unreliable for identifying the hemodynamic significance of coronary lesions. In patients with chronic multivessel CAD, measuring fractional flow reserve (FFR) to assess the physiologic significance of a coronary lesion yields better outcomes than angiographically guided PCI. Investigators have now studied that approach…