Myelin Oligodendrocyte Glycoprotein Antibodies in Cerebral Spinal Fluid

Certain antibody-mediated diseases of the central nervous system are best measured in cerebrospinal fluid (CSF). To evaluate the diagnostic utility of myelin oligodendrocyte glycoprotein (MOG) antibody testing in CSF, investigators evaluated 74 patients with true-positive CSF antibodies for MOG antibody disease (MOGAD), 73 with false-negative antibodies, and 18 false-positive test results (in patients with diagnoses other than MOGAD).

CSF MOG antibody testing had a sensitivity of 90% and specificity of 98% for MOGAD. Serum-negative but CSF-positive MOG antibodies were found in 9 (11%) of 83 patients with MOGAD diagnosed clinically. Of the patients with low-positive serum MOG antibodies, significantly more patients with MOGAD than disease con…