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Evidence suggests that risks for orthostatic hypotension and falls are elevated immediately after initiation of antihypertensive medication. However, little is known about the association between antihypertensive medication initiation and fracture risk among older nursing home residents, who commonly receive these medications.
In a retrospective cohort study of Veterans Affairs (VA) nursing home residents during 2006 to 2019, researchers identified 13,000 residents who initiated a first or additional antihypertensive medication and 52,000 propensity score–matched controls (mean age, 78). The primary outcome was a composite of pelvic fracture, surgically treated hip fracture, and fractures of the humerus, radius, and ulna that required interv…