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Hypokalemia is common in hospitalized patients and often is associated with electrocardiogram (ECG) abnormalities. However, the prevalence and clinical significance of these findings has not been established. Researchers in Denmark and Sweden performed a multicenter cohort study of 80,000 adult patients who presented to emergency departments (EDs). Patients with hyperkalemia (defined in this study as potassium level >4.4 mmol/L) were excluded.
The incidence of hypokalemia (potassium level, <3.5 mmol/L) was 9.0%. ECG abnormalities were present in 40% of hypokalemic patients and included t-wave flattening/inversion, ST-segment depression, QTc prolongation, longer QRS duration, and high heart rate. Hypokalemia was associated with excess risk fo…