Are Prediagnostic Caffeine Metabolites Associated with Incident Parkinson Disease?

Analysis of data from the large EPIC4PD cohort suggests so.

Could the well-documented association of caffeine intake with reduced incidence of Parkinson disease (PD) be due to its metabolites? Researchers addressed this question by using a case-controlled study that was nested within their larger EPIC4PD cohort, part of a longitudinal, multinational European study. They focused on incident PD cases and matched these to a control group with similar age, sex, study center, and fasting status. High-resolution mass spectrometry was performed on plasma to identify potential caffeine metabolites.

There were 351 incident Parkinson cases and 351 controls matched for age, sex, study center, and fasting status at blood sampling. In addition to caffeine, the paraxanthine and theophylline metabolites of caffeine…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)