Androgen-Deprivation Therapy Use and Duration in Postoperative Patients with Prostate Cancer

Radiotherapy (RT) combined with androgen-deprivation therapy (ADT) has long been the established standard of care for treating patients with localized or locally advanced prostate cancer. However, in men with biochemical failure after prostatectomy, the role of this combination is less well established. To learn more, investigators conducted RADICALS-HD, an international, multicenter study of post-prostatectomy patients with PSA values less than 5 ng/mL and no metastatic disease on bone scan or computed tomography.

Although the study was designed as a three-way randomization of patients receiving RT, the researchers later chose to separately evaluate two comparisons: RT alone versus RT plus short-course ADT (SC-ADT; 6 months), and RT plus SC…