Omega-3 Fatty Acids for Patients with Knee Osteoarthritis?

This randomized study showed no benefit for krill oil, a source of high-bioavailablity ω-3 fatty acids.

Patients with knee osteoarthritis (OA) often are told to take ω-3 fatty acids (fish oil) to “lubricate their joints” — sometimes by orthopedists who also recommend hyaluronic acid injections. Neither of these treatments is supported by the American College of Rheumatology (Arthritis Rheumatol 2020; 72:220). In this Australian study, researchers explored the specific value of krill oil, which has higher bioavailability of ω-3 fatty acids than does fish oil, and contains an additional antioxidant, astaxanthin. About 260 patients (mean age, 62) with painful knee OA and with joint effusion and synovitis identified on magnetic resonance imaging were randomized to krill oil (2 g daily, containing 350 mg of ω-3 fatty acids) or placebo.

At 24 weeks'…

Reviewing Author

Thomas L. Schwenk, MD

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Thomas L. Schwenk, MD

Disclosures

Editorial BoardsUpToDate

Omega-3 Fatty Acids for Patients with Knee Osteoarthritis?

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Reviewing Author