Pulsed-Field Ablation in Paroxysmal Atrial Fibrillation: 1-Year inspIRE Outcomes

Pulsed-field ablation (PFA) is currently the darling of electrophysiology, and various PFA systems are under development and testing. Preliminary results from the prospective, multicenter, single-arm inspIRE trial (NCT04524364) of the non–FDA-approved Varipulse system showed effectiveness and safety for paroxysmal atrial fibrillation (AF). Now, the investigators report final 1-year results.

The cohort included 186 patients (mean age, 59 years; 30% women; mean CHA₂DS₂-VASc score, 1.3).

Results were as follows:

• Only one acute adverse event — a case of urinary retention — was reported.

• The primary effectiveness endpoint — complete pulmonary vein isolation and freedom from any atrial arrhythmia at 12 months — was achieved in 76% of patients.

• Freedom…