Oral vs. Intravenous Iron for Treating Iron Deficiency in Patients with Restless Legs Syndrome

Restless legs syndrome (RLS) can be a complication of iron deficiency. In this randomized trial, researchers compared the effectiveness of oral and intravenous iron in 94 patients with RLS and documented iron-deficiency anemia. Patients received either a 6-week course of oral ferrous sulfate (325 mg twice daily, with vitamin C) or 2 intravenous (IV) infusions of ferumoxytol, given several days apart. Oral and IV placebos were given as appropriate to maintain blinding.

At baseline, participants' mean score on a 40-point standardized RLS symptom scale was 22, indicating moderate-to-severe RLS. At 6 weeks, scores improved by 8 points in the IV group and 10 points in the oral group — a nonsignificant difference. About half the patients in the or…