Which Neuroimaging Tool Best Predicts Conversion from Mild Cognitive Impairment to Dementia?

Tau PET performed better than amyloid PET or and brain MRI in predicting conversion from mild cognitive impairment to dementia.

Neuroimaging may assist in identifying conversion from mild cognitive impairment (MCI) to dementia. In this international, multicenter study, researchers analyzed tau positron emission tomography (PET), amyloid-β (Aβ) PET, and brain magnetic resonance imaging (MRI) data to determine which best predicted this clinical progression. Quantitative neuroimaging measures included tau-PET temporal region of interest, global Aβ PET, and MRI regional cortical thickness scores in an Alzheimer disease (AD) signature region. Visual read measurements included assessments of neocortical tau-PET, global Aβ PET, and medial temporal atrophy on MRI. Neuroimaging was performed within 1 year of MCI diagnosis. Outcomes included clinical diagnoses of all-cause de…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Which Neuroimaging Tool Best Predicts Conversion from Mild Cognitive Impairment to Dementia?

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Reviewing Author