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Despite mostly negative results from prior studies about mortality benefits of multivitamins, multivitamin use continues to be ubiquitous and is viewed by many patients as a cheap, safe, and easy way to improve dietary quality and health outcomes. Investigators addressed what they considered to be inadequacies of prior research by pooling data from three large observational cohort studies with nearly 400,000 participants (median age, 62) who were followed for as long as 27 years (mean, 20 years); these studies included data on diet, self-reported multivitamin use, and mortality.
In adjusted analyses, daily multivitamin use was associated with a very small, but significant (4%), higher all-cause mortality risk. Cause-specific mortality from h…