Is It Necessary to Wait 4 Weeks Between Live Virus Vaccination and Liver Transplantation?

In children with chronic liver disease, longitudinal monitoring of plasma nucleic acids indicated that clearance of vaccine viral strains often occurred within 2 weeks.

Guidelines recommend deferring solid organ transplantation for 4 weeks after administering live virus vaccines; however, particularly in children with organ failure, this can result in skipping such vaccines entirely to avoid passing up chances for transplantation (the issue also arises for adults who are not immune to varicella-zoster virus [VZV] or who require additional measles, mumps, and rubella [MMR] vaccination). To determine whether the 4-week delay is necessary, investigators serially measured measles virus RNA or VZV DNA in plasma samples from children with or without chronic liver disease (CLD) after receipt of MMR or VZV vaccination. In all, 21 participants with CLD (aged 6–13 months) and 13 healthy controls (aged 6–14 months) r…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Is It Necessary to Wait 4 Weeks Between Live Virus Vaccination and Liver Transplantation?

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Reviewing Author