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Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication that negatively affects quality of life and may limit adherence to further cancer-directed therapy. Effective options for prevention are limited. In a multicenter, randomized trial conducted in Germany, investigators compared standardized twice-weekly neuromuscular exercise training versus standard care in adult patients receiving first-line chemotherapy. Randomization was stratified according to type of chemotherapy (oxaliplatin or vinca alkaloid) and age.
One hundred fifty-eight patients (mean age, 49; 59% male) were randomized to one of three groups: standard care alone or standard care plus a program of either sensorimotor or whole-body vibration training with a s…