Is Intracranial Atherosclerotic Disease Associated with Dementia Risk?

After adjustment for known risk factors, ICAD was associated with elevated dementia risk at 5 years.

Although intracranial atherosclerotic disease (ICAD) is a known risk factor for cerebrovascular ischemic events, its potential role in dementia risk remains unclear. The Atherosclerosis Risk in Communities (ARIC) study was a prospective cohort study that recruited participants from four U.S. communities. From 2011 to 2013, a subset comprising 1590 participants (mean age, 77; 40% men; 28% Black) underwent ICAD evaluation and neurocognitive testing to ascertain the prospective association of ICAD with dementia risk, independent of other known cardiovascular risk factors. ICAD was diagnosed based on focal-wall thickness on brain MRI, with or without luminal stenosis on magnetic resonance angiography (MRA).

During a median follow-up of 5.6 years…

Reviewing Author

Shea E. Hogan, MD, MSCS, FACC, FSCAI, FSVM

Disclosures

Editorial BoardsVascular Medicine

Shea E. Hogan, MD, MSCS, FACC, FSCAI, FSVM

Disclosures

Editorial BoardsVascular Medicine

Is Intracranial Atherosclerotic Disease Associated with Dementia Risk?

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Reviewing Author