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Chronological age is an imperfect marker of “biological” aging, defined as the loss of physiological integrity and function over time. During the past 30 years, several approaches, particularly telomere length and epigenetic clocks, have been used to identify cells that have aged more rapidly than others in an average person. Now, an international team investigated whether blood proteomics also could predict biological aging.
The team measured levels of nearly 3000 blood proteins in 45,000 people in the U.K. Levels of ≈200 of these proteins collectively predicted biological age. Characteristics that were more likely among people whose “proteomic age” was greater than their chronological age were as follows:
Established aging markers, such as …