Does Thrombectomy for Acute Ischemic Stroke Have an Intermediate-Term Benefit?

With follow-up extended to 2 years, functional independence was significantly better in patients treated with thrombectomy in the 6- to 24-hour time window than in patients treated with medical therapy alone.

Selected patients with acute ischemic stroke who are treated in the 6- to 24-hour time window after ischemic stroke onset can benefit from endovascular thrombectomy (EVT). Some previous clinical trials selected patients based on perfusion imaging, which is not available at all centers. The partially industry-funded, phase 3, MR CLEAN-LATE trial determined eligibility based on the appearance of collateral vessels on computed tomographic angiography (CTA). The trial previously showed a benefit at 90 days (NEJM JW Neurol May 11 2023 and Lancet 2023; 401:1371). In this prespecified analysis, the authors assessed outcomes at 2 years.

Over a 4-year period, researchers randomly assigned 502 patients (mean age, 74 years; 52% women) in the 6- to 24-h…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Does Thrombectomy for Acute Ischemic Stroke Have an Intermediate-Term Benefit?

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Reviewing Author