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Historically, aiming for a cure in patients with stage IV melanoma has seemed an unrealistic goal or sometimes a lucky exception. In an international, industry-sponsored, phase 3 study, researchers previously reported better survival outcomes for patients who received nivolumab-containing immunotherapy regimens after 3 years of follow-up (N Engl J Med 2017; 377:1345) and after 6.5 years (J Clin Oncol 2022; 20:127) compared with ipilimumab monotherapy. Now, with a minimum follow-up of 10 years, they report the final analysis of the outcome.
Median overall survival at 10 years was significantly longer in the nivolumab-ipilimumab and nivolumab arms than in the ipilimumab arm (71.9 and 36.9 vs. 19.9 months). Among patients who were alive and wit…