Do Children Need a Booster of Typhoid Conjugate Vaccine?

Perhaps yes: In a trial in Bangladesh, typhoid vaccine effectiveness waned within 5 years after a single dose (especially in the youngest children).

The World Health Organization recommendation of a single dose of typhoid conjugate vaccine (TCV) for children in high-burden countries is based on clinical trials in which participants were followed for 2 years. To assess durability of protection, investigators conducted additional follow-up of 44,000 children in Bangladesh who were initially assigned (at age 9 months–15 years) to receive either TCV or Japanese encephalitis vaccine. Participants who received Japanese encephalitis vaccine were given TCV at their final visit. In this study, follow-up was extended to 5 years and vaccine effectiveness was assessed in children recently immunized with TCV (i.e., at the last study visit) compared with those vaccinated in the original trial.

During …

Reviewing Author

Anna Wald, MD, MPH

Disclosures

Consultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)

RoyaltiesUpToDate

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris

Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases

Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)