Another Look at Whether Paternal Metformin Is Associated with Congenital Malformations

In a new cohort study, the association disappeared after careful adjustment for possible confounders.

In a 2022 observational study from Denmark, researchers reported that offspring of men who took metformin during the 3 months before conception (the period of sperm development) were statistically more likely to have congenital malformations than were children whose fathers were unexposed to metformin (NEJM JW Gen Med May 15 2022 and Ann Intern Med 2022; 175:665). However, a subsequent cohort study from Israel did not confirm the Danish findings (NEJM JW Gen Med Jul 15 2024 and Ann Intern Med 2024; 177:851).

Now a third group has examined this issue. Investigators identified 600,000 children born in Norway and 2.6 million children born in Taiwan for whom paternal exposure to metformin during spermatogenesis could be determined from national …

Reviewing Author

Bruce Soloway, MD

Disclosures

Editorial BoardsNew RoAR News (http://www.newroarnews.org)

Bruce Soloway, MD

Disclosures

Editorial BoardsNew RoAR News (http://www.newroarnews.org)

Another Look at Whether Paternal Metformin Is Associated with Congenital Malformations

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Reviewing Author