Which Patients with Cardiogenic Shock Are at Risk for Early Death?

While clinicians cannot modify effects of older age and comorbidities, they can advocate for early revascularization, associated with lower mortality.

Cardiogenic shock is a deadly condition, with some studies showing early mortality over 50%. To determine factors associated with early mortality (in hospital or within 30 days) in patients with cardiogenic shock, researchers performed a systematic review and meta-analysis of 160 studies (mostly retrospective cohort studies) involving almost 2.5 million patients.

Median early mortality was 41.4%. Associations with greater early mortality included:

Patient factors, such as age ≥75 years, malignancy, prior peripheral arterial disease, chronic kidney disease, valvular disease, and female sex.
Presentation factors, such as in-hospital and out-of-hospital cardiac arrest, left main culprit artery, left ventricular ejection fraction <30%, dialysis, a…

Reviewing Author

Karol E. Watson, MD, PhD, FACC

Disclosures

Consultant/Advisory BoardBoehringer Ingelheim; Amgen; Novartis; Lilly; Amarin

Speaker’s BureauBoehringer Ingelheim

Grant/Research SupportNIH

Editorial BoardsCirculation (Associate Editor)