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Gabapentinoids can cause gait disturbance, drowsiness, and dizziness, which could raise risk for falls and fractures, especially among older patients. To evaluate the association between gabapentinoids and risk for hip fracture, Australian researchers used a database of linked health records to identify ≈2600 patients (age, ≥50) hospitalized with hip fractures between 2013 and 2018 who also had prescriptions for gabapentinoids (pregabalin in 94% of cases).
The researchers used a case–crossover design (i.e., patients served as their own controls over time) to examine the temporal relation between gabapentin exposure and hip fracture. After adjusting for comorbidities, relevant medication use (e.g., benzodiazepines, opioids), and increased gab…