Can the Life's Essential 8 Construct Identify Risk for Poor Brain Health Outcomes?

Suboptimal cardiovascular health scores on the LE8 construct led to poor brain health outcomes in two large cohorts of middle-aged adults.

Midlife cardiovascular health (CVH) may affect brain health. One validated CVH construct is the American Health Association Life's Essential 8 (LE8), which includes blood pressure, non–high-density lipoprotein blood cholesterol, blood glucose, smoking, physical activity, diet, body-mass index (BMI), and sleep duration. In this study, researchers assessed the association between CVH and poor brain health outcomes in a discovery cohort of 316,127 participants (mean age, 56 years; 52% female; mean follow-up, 4.9 years) and a replication cohort of 68,407 participants (mean age, 56 years; 60% female; mean follow-up, 2.9 years). LE8 scores range from 0 to 100, and CVH was categorized as poor with scores <20; intermediate with scores of 20–80 and …

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Can the Life's Essential 8 Construct Identify Risk for Poor Brain Health Outcomes?

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Reviewing Author