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Prion diseases are a group of fatal neurodegenerative disorders caused by misfolded isoforms of normal cellular proteins known as prion proteins, which lead to progressive neurodegeneration. Creutzfeldt-Jakob disease (CJD) is the most common human prion disease. Real-time quaking-induced conversion (RT-QuIC) is a highly sensitive and specific diagnostic tool for prion diseases currently used on cerebrospinal fluid (CSF) samples. The objective of this study was to determine whether aggregates of misfolded prion proteins in skin biopsies serve as a more sensitive diagnostic biomarker for prion diseases compared with those in CSF. The study included 101 patients diagnosed clinically with prion-related diseases (PRDs; mean age, 61 years; 62% fe…