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Traditionally, non–Staphylococcus aureus bacteremic infections have been most commonly managed with 14 days of intravenous antibiotic therapy. But given the safety and effectiveness of shorter-duration therapy for many nonbacteremic infections, the necessary length of treatment for bacteremia has been questioned. Investigators conducted an international, randomized noninferiority trial to assess 7 days compared with 14 days of antibiotic therapy in hospitalized patients with bloodstream infections. Patients were excluded if they had infections with S. aureus, were neutropenic, were severely immunocompromised, had prosthetic heart valves or endovascular grafts, or had other indications for more-prolonged therapy. The primary outcome was 90-d…