Mounting Incidence of Parvovirus B19 Infection and Associated Consequences

In the U.S. in 2024, diagnoses of B19 infection as well as its complications in pregnancy, immunodeficiency, and sickle cell disease have all been on the rise.

Infection with human parvovirus B19 (B19; fifth disease) usually results in a mild childhood condition consisting of fever and a characteristic “slapped cheek” rash; nonetheless, serious symptoms can occur in those who are pregnant, immunocompromised, or have sickle cell disease. Now, three U.S. studies on B19 have been simultaneously published.

Authors of the first study described a marked increase in documented B19 infections. Cases were identified by IgM antibody titers or nucleic acid amplification (NAAT) assays; 93% of samples were from adults. Peaks in 2024 (post–COVID-19) were compared with those in 2018–2019 (pre–COVID-19) and 2020–2023 (during COVID-19). Pre–COVID-19, annual patterns of B19 were typical (i.e., seasonal crests in Apr…

Reviewing Author

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Mounting Incidence of Parvovirus B19 Infection and Associated Consequences

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Reviewing Author