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Individualizing antibiotic duration in sepsis could limit antibiotic-associated adverse events, but the effect on treatment efficacy is unknown. In this multicenter noninferiority trial, researchers enrolled 2700 critically ill adults (mean age, 60) in 41 U.K. intensive care units who required antibiotics for suspected sepsis. Patients were randomized to usual care, antibiotic discontinuation based on daily procalcitonin measurement, or antibiotic discontinuation based on daily C-reactive protein (CRP) measurement. Clinicians were blinded to group allocation and, instead of receiving biomarker values, received daily automated advice on antibiotic continuation based on whether the biomarker had fallen below a predetermined cutoff or to a per…