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Calcium pyrophosphate deposition (CPPD) disease has acute and chronic manifestations that can coexist with — or mimic — other rheumatologic disorders. In this report, rheumatologists who recently developed classification criteria for CPPD disease present a series of 618 patients from 7 countries who met those criteria. Selected findings are as follows:
Virtually all patients had one or more episodes of acute CPP crystal arthritis. The most common sites of involvement for patients with recurrent acute flares were knees and wrists.
26% of patients had persistent inflammatory arthritis, associated significantly with episodic acute wrist arthritis and with osteoarthritis at the scapho-trapezo-trapezoid joint and the second or third metacarpo-phal…