Does Use of Drug-Coated Devices Improve Outcomes in Chronic Limb-Threatening Ischemia?

No, according to a randomized trial in the U.K.

Lower extremity revascularization (LER) is a class I indication for chronic limb-threatening ischemia (CLTI), but the most effective LER approach has not been established. In this phase 3 trial, investigators randomized patients with CLTI to receive endovascular LER with one of three approaches: drug-coated balloon angioplasty with or without bare metal stent, drug-eluting stent placement, or plain balloon angioplasty with or without bare metal stent (ISRCTN14469736). The primary outcome was amputation-free survival.

The study included 480 participants in the U.K. (mean age, 72 years; 35% women; 26% current smokers). The majority of patients were receiving an anticoagulant or antiplatelet agent (87%) and medical therapy for hypercholesterole…

Reviewing Author

Shea E. Hogan, MD, MSCS, FACC, FSCAI, FSVM

Disclosures

Editorial BoardsVascular Medicine

Shea E. Hogan, MD, MSCS, FACC, FSCAI, FSVM

Disclosures

Editorial BoardsVascular Medicine

Does Use of Drug-Coated Devices Improve Outcomes in Chronic Limb-Threatening Ischemia?

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Reviewing Author