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The creation of each year's influenza vaccine always involves some educated guesswork to anticipate patterns in circulating viral strains; the same now applies to COVID-19 vaccines. Enough data for both infections has accumulated to allow preliminary assessments of each vaccine's 2024–2025 winter performance.
Four nationwide surveillance networks tallied confirmed flu cases among ≈150,000 children and adults, both inpatients and outpatients, with acute respiratory illnesses. Estimated vaccine efficacy among children and adolescents (age, <18 years) ranged from 32% to 60% against infection and from 63% to 78% against hospitalization. Estimated vaccine efficacy among adults ranged from 36% to 54% against infection and 41% to 55% against hospit…