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Corticosteroids have been the mainstay of therapy for patients with severe acute alcohol-associated hepatitis for longer than 50 years — and a 4-week course of prednisolone (40 mg daily) is recommended in current guidelines (Am J Gastroenterol 2024; 119:30). However, infection risk can be high with steroid treatment. Multinational investigators conducted an unblinded trial in 254 adults (age, <70; mean age, 41), with severe alcohol-associated hepatitis (defined as Maddrey Discriminant Function ≥32 or MELD score ≥21); patients were randomized to receive 4 weeks of prednisolone either as fixed dose (40 mg daily) or tapered dose (starting at 40 mg daily, tapered by 10 mg daily each week). Patients with elevated Lille score (i.e., nonresponders…